The beloved star, who was known for his role as Lafayette Reynolds in the HBO vampire series, passed away following heart failure.
“Nelsan has passed away after complications with heart failure,” said his manager Emily Gerson Saines.
She went on to tell The Hollywood Reporter: “He was a great talent, and his words and presence will be forever missed.”
His co-stars immediately took to Twitter to share their condolences after the tragic news emerged online.
Kevin Alejandro posted: “I am speechless…I am heartbroken…Rest In Peace my friend @OfficialNelsan.”
Anna Paquin went on: “It was an utter privilege to work with the phenomenally talented and deeply kind soul. @OfficialNelsan I’m devastated by his untimely death.”
Stephen Moyer added: “Nelsan Ellis was truly remarkable. A brilliant, charismatic, intelligent, soulful, wonderful dude. This is just completely tragic,” with him also sharing an extremely lengthy heartfelt post on Instagram.
Michael Raymond-James shared: “Unbelievably sad news. Nelsan was such a sweet, gentle soul with an enormous talent. He will be missed greatly RIP.”
Sam Trammell said: “I don’t know if I’ve ever seen the level of humility and kindness that came with the Magnificent Talent that Nelsan Ellis had. Miss u friend (sic).”
Joe Manganiello went on: “Crushed today by the loss of my friend and castmate Nelsan Ellis. He was a wonderful person, a pioneer, and a one of a kind artist. RIP.”
Charlaine Harris added: “I am so sad about the death of Nelsan Ellis, a great talent gone too soon. Such a shock.”
Todd Lowe continued: “So blessed to share the screen with you you beautiful man.”
Carrie Preston posted a sweet picture, with the message: “Dearest #NelsanEllis, may flights of angels sing thee to thy rest, you phenomenally talented genius….”